ea0032p728 | Obesity | ECE2013
Reiter Marie Helene
, Kiefer Florian
, Zeyda Maximilian
, Kopecky Chantal
, Stulnig Thomas
, Luger Anton
, Vila Greisa
The serum- and glucocorticoid-regulated kinase 1 (Sgk1) is a direct transcriptional target of glucocorticoids and is post-translationally activated by the insulin/IGF1 pathway. Distinct polymorphisms in the Sgk1 gene are associated with increased body weight and type 2 diabetes. Here we investigate the expression and regulation of Sgk1 in human obesity.In both omental and subcutaneous human adipose tissue, Sgk1 expression is significantly increased in 20...